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Abstract #3229

Computational Fluid Dynamics of Pulmonary Circulation Before and After Induced Pulmonary Hypertension: 2D Flow versus 4D Flow MRI-Based Boundary Conditions

Sylvana García-Rodríguez1, James Leschke2, Alejandro Roldán-Alzate1,3, and Christopher J. François1

1Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States, 2Rocky Vista University, CO, United States, 3Department of Mechanical Engineering, University of Wisconsin - Madison, Madison, WI, United States

Acute pulmonary hypertension was induced in dogs by micro embolization. RHC was performed, as well as 4D flow MRI pre and post-embolization. MRI data was used to develop a CFD model of the proximal pulmonary circulation while comparing two inlet boundary conditions: velocity definition as defined from 2D flow MRI and from 4D flow MRI, which takes into account the directionality of the velocity. WSS tended to decrease post-embolization. Pressure gradient distribution shows that during peak systole, a constant normal inlet condition might be sufficient for CFD simulation; however, differences might be present during diastole.

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