Abstract #3245

Estimating extraction fraction and blood flow by combining first-pass myocardial perfusion and T1 mapping results

Devavrat Likhite¹, Promporn Suksaranjit², Ganesh Adluru¹, Chris McGann², Brent Wilson², and Edward DiBella¹

¹Department of Radiology and Imaging sciences, University of Utah, Salt Lake City, UT, United States, ²Division of Cardiovascular Medicine, University of Utah, Salt Lake City, UT, United States

Dynamic contrast enhanced MRI is maturing as a tool in contemporary cardiovascular medicine. However, there are challenging areas that have not been fully understood, such as modeling extraction of the contrast agent from the vasculature to the extravascular space. We present a technique that exploits information overlap between two different cardiac MRI techniques, namely, DCE-MRI and T1 mapping, in order to estimate extraction and flow. Our study shows that extraction fraction and myocardial blood flow can be estimated by fixing extracellular volume (ECV) to values obtained from T1 mapping.

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