First and second order motion compensated convex optimized diffusion encoding (CODE-M1M2) enables robust, high resolution cardiac diffusion tensor imaging (cDTI). However, timing of the diffusion encoding relative to the cardiac cycle still requires careful evaluation to achieve precise and accurate measurements. In this study, CODE-M1M2 cDTI was acquired in healthy volunteers at both mid-systole and diastole to identify differences in fiber orientation, fiber cone of uncertainty (CoU), mean diffusivity (MD) and fractional anisotropy (FA). While fiber orientations were equivalent, lower CoU, lower MD, and higher FA were observed in mid-systole than in diastasis indicating improved performance.
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