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Abstract #3302

Phosphorescence Lifetime Imaging to validate BOLD MRI Derived blood PO2

Jon Thacker1, Anthony E. Felder2, Pottumarthi V Prasad1,3,4, and Mahnaz Shahidi2

1Northwestern University, Evanston, IL, United States, 2University of Illinois at Chicago, 3NorthShore University HealthSystem, 4University of Chicago

BOLD MRI measurements are the only non-invasive method sensitive to renal oxygenation. In a previous study we showed that BOLD MRI measurements can be combined with a statistical model to estimate renal oxygenation in rat kidneys. In this study, we examine the use of phosphorescence lifetime imaging (PLI) as a potential method for refining the model. It is important to differentiate between blood and tissue PO2, which is a key benefit of PLI. We found that the PLI is sensitive to changes following LNAME. However, the absolute PO2 values were lower than those estimated by BOLD MRI and possible reasons are discussed.

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