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Abstract #3309

A preliminary study of in-vivo visualization of oxide oxide enhancement in focal inflammatory lesion of lung parenchyma using a 3D radial gradient-echo-based UTE sequence (CODE)

Soon Ho Yoon1, Suh-Young Lee2, Chanhee Lee3, Jinil Park3,4, Jin Mo Goo1, and Jang-Yeon Park3,4

1Department of radiology, Seoul National University Hospital, Seoul University College of Medicine, Seoul, Korea, Republic of, 2Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea, Republic of, 3Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon-si, Gyeonggi-do, Korea, Republic of, 4Department of Biomedical Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea, Republic of

Dual-echo ultrashort echo-time CODE pulmonary MRI preliminarily succeeded in generating a positive contrast of iron oxide in rabbits with granulomatous lung disease, by using clinically-usable superparamagnetic iron-oxide nanoparticles, ferumoxytol, which was hardly achievable via conventional T2* MR sequence. This new pulmonary MR imaging biomarker possibly gives a chance to differentiate a benign inflammatory lesion from malignancy.

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Abstract