Abstract #3309

A preliminary study of in-vivo visualization of oxide oxide enhancement in focal inflammatory lesion of lung parenchyma using a 3D radial gradient-echo-based UTE sequence (CODE)

Soon Ho Yoon¹, Suh-Young Lee², Chanhee Lee³, Jinil Park^3,4, Jin Mo Goo¹, and Jang-Yeon Park^3,4

¹Department of radiology, Seoul National University Hospital, Seoul University College of Medicine, Seoul, Korea, Republic of, ²Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea, Republic of, ³Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon-si, Gyeonggi-do, Korea, Republic of, ⁴Department of Biomedical Engineering, Sungkyunkwan University, Suwon-si, Gyeonggi-do, Korea, Republic of

Dual-echo ultrashort echo-time CODE pulmonary MRI preliminarily succeeded in generating a positive contrast of iron oxide in rabbits with granulomatous lung disease, by using clinically-usable superparamagnetic iron-oxide nanoparticles, ferumoxytol, which was hardly achievable via conventional T2* MR sequence. This new pulmonary MR imaging biomarker possibly gives a chance to differentiate a benign inflammatory lesion from malignancy.

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