Abstract #3321

Ultra-Short Echo Time MRI Quantification of Airspace Enlargement in Bronchopulmonary Dysplasia and Alpha-1 Antitrypsin Deficiency: Parenchyma Destruction, Air trapping or Both?

Heather M Young¹, Dante PI Capaldi¹, Khadija Sheikh¹, David M McCormack², Cory M Yamashita², and Grace Parraga¹

¹Robarts Research Institute, London, ON, Canada, ²Division of Respirology, The University of Western Ontario, London, ON, Canada

UTE MRI signal-intensity has not yet been evaluated in young patients with AATD and BPD, where there may be different mechanisms of parenchyma and airway destruction. There is the potential to demonstrate UTE MRI as a quantitative-measurement-tool for longitudinal and treatment-response evaluations in these vulnerable patients. We evaluated UTE MRI and CT using -950HU and -856HU radiodensity-thresholds, and a ‘sliding-threshold’ for the UTE image, identifying regions with low-signal-intensity for multiple threshold values. Regions of normalized UTE signal-intensity <29 suggest airspace enlargement, and demonstrate the potential utility of UTE MRI in quantifying this without ionizing-radiation in AATD and BPD subjects.

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