Abstract #3342

Towards Achieving the Optimal SNR Efficiency for 3D Multi-shot Diffusion-Weighted Echo-Planar Imaging

Xiaoxi Liu¹, Edward S. Hui^1,2, Cui Di¹, Nan-Kuei Chen^3,4, and Hing-Chiu Chang¹

¹Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, ²The State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, ³Department of Biomedical Engineering, University of Arizona, Tucson, AZ, United States, ⁴Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States

Due to the assumption of 2D phase variations, the feasible maximum slab thickness is relatively thin (e.g. < 25 mm) for 3D multi-shot diffusion-weighted echo-planar imaging. We have thus proposed a new method in another study to correct for 3D inter-shot phase variations, thereby significantly increasing the feasible maximum slab thickness. In this study, we have demonstrated by simulations and experiments that slab thickness can be significantly increased to allow whole brain coverage with a TR that achieves optimal SNR efficiency.

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