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Abstract #3345

A measurement weighting scheme for optimal powder average estimation

Filip Szczepankiewicz1, Carl-Fredrik Westin2,3, and Hans Knutsson3,4

1Medical Radiation Physics, Lund University, Lund, Sweden, 2Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, 3Department of Biomedical Engineering, Linköping University, Linköping, Sweden, 4Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden

The powder-averaged signal is used in several analysis techniques in diffusion MRI. Assuming uniformly distributed diffusion encoding directions, it is calculated simply as the arithmetic signal average. However, perfectly uniform sampling is generally unattainable.

We demonstrate how non-uniformity can be accounted for by using weighted signal averaging, and we describe how optimal weights can be calculated for existing diffusion encoding schemes to yield improved accuracy of the powder average estimate.

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