Abstract #3345

A measurement weighting scheme for optimal powder average estimation

Filip Szczepankiewicz¹, Carl-Fredrik Westin^2,3, and Hans Knutsson^3,4

¹Medical Radiation Physics, Lund University, Lund, Sweden, ²Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States, ³Department of Biomedical Engineering, Linköping University, Linköping, Sweden, ⁴Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden

The powder-averaged signal is used in several analysis techniques in diffusion MRI. Assuming uniformly distributed diffusion encoding directions, it is calculated simply as the arithmetic signal average. However, perfectly uniform sampling is generally unattainable.

We demonstrate how non-uniformity can be accounted for by using weighted signal averaging, and we describe how optimal weights can be calculated for existing diffusion encoding schemes to yield improved accuracy of the powder average estimate.

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