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Abstract #3361

Does artifact correction in spinal cord DTI improve sensitivity at the group level?

Gergely David1,2, Patrick Freund1,3,4, and Siawoosh Mohammadi2,4

1Spinal Cord Injury Center, Balgrist University Hospital, Zurich, Zurich, Switzerland, 2Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, 3Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, United Kingdom

In this manuscript, we investigate how application of established post-processing methods (spatial registration and robust tensor fitting) and of a newly introduced outlier rejection technique referred to as reliability masking influence the statistical power of a clinical spinal cord DTI study. The assessment was performed using a previously published clinical dataset investigating microstructural correlates of spinal degeneration in cervical spondylotic myelopathy (CSM). We found that the established post-processing methods had almost no influence on the statistical power by which the microstructural differences is observed, whereas reliability masking increased the statistical power by more than 13%.

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