Meeting Banner
Abstract #3374

Microstructural alteration of amygdala-hippocampus-nucleus accumbens circuit in methamphetamine users : an in vivo diffusion tensor imaging study

Yadi Li1, Haibo Dong1, Feng Li1, Gaoyan Wang1, Nadan Zhao1, Yong Zhang2, and Wenhua Zhou3

1Radiology, Lihuili Hospital, Ningbo, People's Republic of China, 2MR Research China, GE Healthcare, Shanghai, People's Republic of China, 3Ningbo Addiction Research and Treatment Center, Ningbo, People's Republic of China

No previous in vivo studies have investigated drug-related changes of microstructural integrity of amygdala-hippocampus-nucleus accumbens circuit using diffusion tensor imaging. This study demonstrated reduced microstructural integrity of this circuit in methamphetamine users by applying automated and semi-automated segmentation techniques to acquire regions of interest. The microstructural impairment of hippocampal subiculum and basolateral amygdala might be implicated in the development of anxiety and psychosis. Enhanced anatomical connectivity between left BLA and bilateral NAc may underlie the relapse of MA intake and production of psychosis.

This abstract and the presentation materials are available to members only; a login is required.

Join Here