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Abstract #3379

White matter microstructural properties are related to inter-individual differences in cognitive instability after sleep deprivation

yuanqiang zhu1,2, lin liu1, tian dai1, ziliang xu1, yibin xi2, hong yin2, and wei qin1

1xidian, xi'an, People's Republic of China, 2xijing hospital, xi'an, People's Republic of China

ract-based spatial statistical analyses was used to investigate whether the individual differences in cognitive instability after SD was related to differences in WM structure. Resistant group exhibited significantly higher FA than vulnerable group, significant negative correlations were found between numbers of psychomotor vigilance task(PVT)lapses and FA in multiple regions. Our results also showed that 63% of individual variability in PVT lapse may be explained by variations in FA within superior longitudinal fasciculus and splenium of the corpus callosum. These findings suggested that cognitive instability after SD is closely associated with individual differences in WM integrity.

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