Various diffusion MRI approaches were suggested to study the complex water diffusion in neuronal tissues and gleaning microstructural information thereof. Nevertheless, to date, only few attempts were done to correlate between the microstructural features obtained from single diffusion encoding (SDE) and double diffusion encoding (DDE) MRI experiments. The main objective of the present study is to compare between the microstructural information obtained from both diffusion MRI methodologies, under similar experimental conditions, when performed on a fixed porcine spinal cord.
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