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Abstract #3390

Comparison of diffusion propagator imaging metrics for accurate microstructure characterization in clinically acceptable scan times

Luis Miguel Lacerda1,2, Gareth John Barker2, and Flavio Dell'Acqua2

1Institute of Child Health, University College London, London, United Kingdom, 2Neuroimaging, King's College London, London, United Kingdom

Despite the abundance of models to describe the diffusion propagator, its usefulness has not yet been explored in a clinical/clinical research setting. In this study, we have compared global diffusion propagator imaging metrics to recently described measures of anisotropy and probability profiles at different displacement scales to characterise microstructure. Moreover, we have shown that these metrics offer complementary information to the ones currently established. Finally we have also acquired a "Reference Dataset" with several different diffusion weightings and demonstrated that by choosing the right combination, accurate reconstruction of both types of metrics is possible for clinically acceptable scan times.

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