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Abstract #3392

The spatial vs. angular resolution trade-off in diffusion MRI explored ex vivo at 9.4T

Giorgia Grisot1,2, Joseph M. Mandeville2, and Anastasia Yendiki2

1Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Athinoula A. Martinos Center for Biomedical Imaging, MGH, Charlestown, MA, United States

The time constraints of in vivo diffusion MRI require a compromise to be made between spatial and angular resolution. Given the lack of ground truth on the configuration of human brain connections, determining the optimal operating point along this trade-off is still an open problem. We use high-SNR ex vivo human data at microscopic resolution to study the effect of spatial and angular resolution on dMRI tractography accuracy. Our findings show that voxel size has a much more dramatic effect on tractography reconstruction of challenging white matter configurations than the number of gradient directions.

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