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Abstract #3459

Reproducibility of DTI Metrics and the Influence of SNR on DTI metrics in a Longitudinal Multicenter Clinical Trial

Xiaopeng Zhou1, Ken Sakaie1, Josef Debbins2, Robert Fox1, and Mark J. Lowe1

1The Cleveland Clinic, Cleveland, OH, United States, 2Barrow Neurological Institute, Phoenix, AZ, United States

SPRINT-MS is a large-scale longitudinal phase II trial including 27 3T MRI scanners to evaluate the treatment of progressive multiple sclerosis with Ibudilast. DTI measures showed high reproducibility in a longitudinal multicenter study, making it appropriate for use as a biomarker. The longitudinal design of the SPRINT-MS trial is expected to mitigate the systematic influence of SNR on DTI, but the observed trend may be useful as a correction factor in cross-sectional studies.

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