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Abstract #3464

The histological validation analysis of diffusional kurtosis imaging with a cleared mouse brain.

Ryusuke Irie1, Koji Kamagata1, Aurelien Kerever2, Suguru Yokosawa3, Yosuke Otake3, Hisaaki Ochi3, Kazuhiko Tagawa4, Hitoshi Okazawa4, Ryo Ueda5, Kohske Takahashi6,7, Kanako Sato1, Masaaki Hori1, Eri Arikawa Hirasawa2, and Shigeki Aoki1

1Radiology, Juntendo University School of Medicine, Tokyo, Japan, 2Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan, 3Research & Development Group, Hitachi Ltd., Tokyo, Japan, 4Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan, 5Radiological Sciences, Tokyo Metropolitan University Graduate School of Human Health Sciences, Tokyo, Japan, 6Psychology, Chukyo University, Nagoya, Japan, 7Araya Brain Imaging, Tokyo, Japan

Diffusional kurtosis imaging (DKI) is a sensitive technique to analyze brain microstructure but that has little histological foundation. In this study, we evaluated a relationship between DKI parameters with neurite density measured by a confocal microscopy of the cleared mouse brain. There was a strongly positive correlation between neurite density and DKI parameters in the caudate nucleus and putamen, whereas the correlation between neurite density and fractional anisotropy was moderate. DKI reflect neurite density in an area with crossing fibers, so that can evaluate more complex microstructures than diffusion tensor imaging.

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