Abstract #3464

The histological validation analysis of diffusional kurtosis imaging with a cleared mouse brain.

Ryusuke Irie¹, Koji Kamagata¹, Aurelien Kerever², Suguru Yokosawa³, Yosuke Otake³, Hisaaki Ochi³, Kazuhiko Tagawa⁴, Hitoshi Okazawa⁴, Ryo Ueda⁵, Kohske Takahashi^6,7, Kanako Sato¹, Masaaki Hori¹, Eri Arikawa Hirasawa², and Shigeki Aoki¹

¹Radiology, Juntendo University School of Medicine, Tokyo, Japan, ²Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Tokyo, Japan, ³Research & Development Group, Hitachi Ltd., Tokyo, Japan, ⁴Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan, ⁵Radiological Sciences, Tokyo Metropolitan University Graduate School of Human Health Sciences, Tokyo, Japan, ⁶Psychology, Chukyo University, Nagoya, Japan, ⁷Araya Brain Imaging, Tokyo, Japan

Diffusional kurtosis imaging (DKI) is a sensitive technique to analyze brain microstructure but that has little histological foundation. In this study, we evaluated a relationship between DKI parameters with neurite density measured by a confocal microscopy of the cleared mouse brain. There was a strongly positive correlation between neurite density and DKI parameters in the caudate nucleus and putamen, whereas the correlation between neurite density and fractional anisotropy was moderate. DKI reflect neurite density in an area with crossing fibers, so that can evaluate more complex microstructures than diffusion tensor imaging.

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