Abstract #3479

The impact of High-Q and High-K on complex fiber structures in the human brain

Iain Bruce¹, Christopher Petty¹, Hing-Chiu Chang², Nan-Kuei Chen^1,3, and Allen W Song¹

¹Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, United States, ²Department of Diagnostic Radiology, University of Hong Kong, ³Biomedical Engineering, University of Arizona, Tuscan, AZ, United States

In this diffusion MRI study, we investigated the impact of high angular resolution (high-Q) and high spatial resolution (high-K) on complex fiber structures. It was found that while high-Q was able to resolve crossing fibers within a given region, high-K provided additional spatial details of these crossing fibers in the same location. In addition, diffusion data from high-K improved characterization of high-curvature fibers, which cannot be adequately resolved with high-Q. It is thus concluded that high-K is preferred when both crossing and high-curvature fibers need to be resolved, as in human connectome analysis.

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