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Abstract #3491

Towards a connectome atlas of the C57Bl6 mouse brain using ex vivo ultra-high field diffusion MRI

Ivy Uszynski1,2, Hervé Mathieu1,2,3,4, Jean-Christophe Deloulme1,2, Emmanuel L. Barbier1,2, and Cyril Poupon5

1Grenoble Institut des Neurosciences, Université Grenoble Alpes, Grenoble, France, 2INSERM U1216, Grenoble, France, 3Unité Mixte de Service IRMaGe, Grenoble Alpes Hospital, Grenoble, France, 4Unité Mixte de Service 3552, CNRS, Grenoble, France, 5NeuroSpin, CEA Saclay, Gif-sur-Yvette, France

Diffusion MRI is a powerful tool to investigate the structural connectivity of the brain and to characterize its microstructure. In this study, we propose to adapt the white matter bundles clustering approach - previously achieved on humans - to the mouse in order to establish the foundations of a novel atlas of the structural connectivity. To this aim, 3D High Angular Resolution Diffusion Imaging (HARDI) was performed ex vivo on C57Bl6 mice brains (100µm isotropic) at 9.4T and clusters of fibers were computed using an automated procedure across the entire brain.

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