Abstract #3501

Differentiating Contributions To Diffusional Kurtosis in the Brain with Symmetrized Double-PFG MRI

Jeffrey Paulsen¹, Iris Yuwen Zhou², and Phillip Zhe Sun^2,3

¹Independent, Boston, MA, United States, ²Athinoula A. Martios Center for Biomedical Imaging, MGH and Harvard Medical School, Charlestown, MA, United States, ³Department of Radiology, University of Illinois at Chicago

Kurtosis imaging enables valuable diagnostics of stroke and other tissue pathologies. It can arise directly from restricted diffusion, but also from sub-voxel heterogeneity in the ADC. Utilizing double diffusion contrast, we are able to remove these heterogeneity contributions. We show this targeted ‘microscopic’ kurtosis contrast yields unique contrast in-vivo in a live rat brain: highlighting white/gray matter boundaries.

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