Purpose: To test the high spatial resolution limits of the white matter fibrography (WMF) technique within the scan time constrains of clinical MRI of about ten minutes total scan time and to optimize the image processing algorithms for rendering the white matter (WM) connectome at the highest level of anatomic detail. Methods: Healthy volunteer was scanned with the quadra-FSE pulse at high spatial resolution in 10min. Results: WMF connectome was constructed using ultra-high b-value (34,000s/mm2) synthetic MRI. Conclusion: High spatial resolution direct rendering of the human brain connectome can be accomplished with a 10min scan.
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