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Abstract #3527

Qualitative and quantitative assessment of intravoxel incoherent motion (IVIM) parameters in hypoxic tumor of a mouse to find a relationship with 18F- misonidazole PET imaging

Eo-Jin Hwang1, Joon-Yong Jung1, Jin Kyoung Oh2, and Mun Young Paek3

1Seoul St.Mary Hospital, The Catholic University of Korea, Seoul, Korea, Republic of, 2Incheon St.Mary Hospital, The Catholic University of Korea, Incheon, Korea, Republic of, 3Siemens Healthcare, Seoul, Korea, Republic of

Intravoxel incoherent motion (IVIM) based analysis of diffusion weighted imaging (DWI) has been suggested as a non-invasive tool to characterize tumor hypoxia, but no study has been performed to directly measure its parameters within the hypoxic tumor regions. In this study, we qualitatively and quantitatively compared IVIM parameters with 18F- misonidazole PET imaging and tested the feasibility of using non-invasive imaging strategy to define tumor hypoxia. Our preliminary result successfully related perfusion fraction values to standardized uptake values (SUVs) from PET and showed a potential of DWI as a tool to evaluate tumor oxygenation.

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