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Abstract #3529

Statistical power and confounds for diffusion MRI microstructure modeling

Robbert Leonard Harms1,2, Rainer Goebel1,2, and Alard Roebroeck1

1Maastricht University, Maastricht, Netherlands, 2Brain Innovation, Maastricht, Netherlands

Using high resolution HCP WU-Minn data and GPU accelerated software (MDT;, the aims of this study were to evaluate dMRI microstructure indices over white matter tracts, evaluate the effect sizes between tracts as an upper limit for effect size of diffusion microstructure indices between subjects and finally the influence of possible confounds on those other aims. We report sizeable effects between tracts within subjects for several indices. Also, two clear confounds for diffusion microstructure studies where identified, first, partial volume effects in small and large cross-section tracts, second, model selection on the number of intra-axonal model compartments.

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