Abstract #3536

White Matter Microstructural Changes in Healthy Aging: The Impact of Free Water Elimination on DTI Metrics

Jordan Chad¹, Ofer Pasternak², David H. Salat³, and J. Jean Chen^1,4

¹Rotman Research Institute, Baycrest Health Sciences, Toronto, ON, Canada, ²Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, ³Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada

A Free Water Elimination (FWE) technique is applied to investigate changes in DTI parameters in the human white matter during healthy aging. Our results suggest that age-related changes in DTI metrics often reflect increased extracellular free water with age. DTI with FWE unmasks the effects of free water, revealing authentic tissue microstructure.

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