We are developing an MRI method to measure acetaminophen toxicity in the liver. We obtained dynamic T1 weighted images of the liver and T1 maps using the clinically approved contrast agent gadoxetate disodium (Eovist). After acetaminophen overdose, the uptake of contrast was decreased in the liver and increased in the kidney. T1 and variation in T1 were higher after acetaminophen. T1 was correlated with ALT, a serum measure of liver damage. This is a promising method for quantifying drug induced liver damage in vivo.
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