We have previously reported molecular MRI studies using Microparticles of Iron Oxide (MPIO) coupled to anti-VCAM-1 antibodies. However, Ultrasmall Superparamagnetic Iron Oxide (USPIO) are more commonly used in MRI applications. Although MPIO provide greater targeting valency and contrast per particle, their advantages over UPSIO for molecular MRI has not been demonstrated empirically. Here, we compared the sensitivity and specificity of VCAM-MPIO and VCAM-USPIO for molecular MRI; VCAM-MPIO, but not VCAM-USPIO, yielded marked and selective contrast in areas of cerebral inflammation. These results confirm the theoretical assumption that MPIO present a more viable platform for molecular MRI than USPIO.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords