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Abstract #3586

Aza-BODIPY Derivative for Gadolinium-enhanced MR and Near-infrared Fluorescence Dual Imaging

Hyunseung Lee1, Eun-jung Kim1, Hyun Min Kim1, and Kwan Soo Hong1,2

1Bio-imaging Research Team, Korea Basic Science Institute, Cheongju, Korea, Republic of, 2Graduate School of Analytical Science and Technology, Chungnam National University

A novel dual imaging probe for in vivo magnetic resonance imaging (MRI) and optical imaging was developed by combining gadolinium (Gd)-chelating MR probe and a near-infrared (NIR) fluorophore, aza-BODIPY (AB; BODIPY = borondipyrromethene). This aza-BODIPY-based bimodal contrast agent (AB-BCA) showed a significant fluorescence emission around the NIR range and an enhanced longitudinal relaxivity in MR modality. The probe was easily delivered to phagocytic cells of the innate immune system, together with macrophages and dendritic cells (DCs), and presented high-performance fluorescence and MR imaging without obvious cytotoxicity.

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