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Abstract #3602

3D CMRO2 Mapping in Human Brain with Direct 17O-MRI: Comparison of Methods for Image Reconstruction and Partial Volume Correction

Dmitry Kurzhunov1, Robert Borowiak1,2,3, Marco Reisert1, Axel Joachim Krafft1, Ali Caglar Özen1, and Michael Bock1

1Dept. of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, 2German Cancer Consortium (DKTK), Heidelberg, Germany, 3German Cancer Research Center (DKFZ), Heidelberg, Germany

This study presents a comparative analysis of different reconstruction techniques for quantification of 3D maps of the cerebral metabolic rate of oxygen consumption (CMRO2) in human brain. CMRO2 maps were calculated from a direct 17O-MRI experiment at 3T in which 17O gas was inhaled. Conventional Kaiser-Bessel reconstruction of 17O MR images was compared to two iterative reconstruction methods using total variation (TV) and anisotropic diffusion (AD) of coregistered proton data as constraints. AD-constraint reconstruction, which acts as a non‑homogeneous edge‑preserving smoothing filter, enabled CMRO2 mapping at clinical field strengths by increasing the SNR, and reducing partial volume effects.

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