This study presents a comparative analysis of different reconstruction techniques for quantification of 3D maps of the cerebral metabolic rate of oxygen consumption (CMRO2) in human brain. CMRO2 maps were calculated from a direct 17O-MRI experiment at 3T in which 17O gas was inhaled. Conventional Kaiser-Bessel reconstruction of 17O MR images was compared to two iterative reconstruction methods using total variation (TV) and anisotropic diffusion (AD) of coregistered proton data as constraints. AD-constraint reconstruction, which acts as a non‑homogeneous edge‑preserving smoothing filter, enabled CMRO2 mapping at clinical field strengths by increasing the SNR, and reducing partial volume effects.
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