Abstract #3602

3D CMRO2 Mapping in Human Brain with Direct 17O-MRI: Comparison of Methods for Image Reconstruction and Partial Volume Correction

Dmitry Kurzhunov¹, Robert Borowiak^1,2,3, Marco Reisert¹, Axel Joachim Krafft¹, Ali Caglar Özen¹, and Michael Bock¹

¹Dept. of Radiology, Medical Physics, Medical Center – University of Freiburg, Freiburg, Germany, ²German Cancer Consortium (DKTK), Heidelberg, Germany, ³German Cancer Research Center (DKFZ), Heidelberg, Germany

This study presents a comparative analysis of different reconstruction techniques for quantification of 3D maps of the cerebral metabolic rate of oxygen consumption (CMRO₂) in human brain. CMRO₂ maps were calculated from a direct ¹⁷O-MRI experiment at 3T in which ¹⁷O gas was inhaled. Conventional Kaiser-Bessel reconstruction of ¹⁷O MR images was compared to two iterative reconstruction methods using total variation (TV) and anisotropic diffusion (AD) of coregistered proton data as constraints. AD-constraint reconstruction, which acts as a non‑homogeneous edge‑preserving smoothing filter, enabled CMRO₂ mapping at clinical field strengths by increasing the SNR, and reducing partial volume effects.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.