Abstract #3611

Optimization of redox-state assessment in rat liver using hyperpolarized [1-13C]alanine

Jae Mo Park^1,2, Ralph E Hurd³, and Daniel M Spielman²

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, Stanford University, Stanford, CA, United States, ³Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

In this study, we demonstrated the strategies of increasing signal sensitivities of ¹³C-pyruvate and ¹³C-lactate generated from an injection of hyperpolarized ¹³C-alanine by (1) adjusting the alanine dose and (2) co-injecting unlabeled pyruvate. 120-mM alanine produced larger amount of labeled pyruvate and lactate as compared to when 80-mM or 40-mM alanine was injected. The co-injection of 7-mM unlabeled pyruvate showed up to 49% SNR increase in pyruvate and lactate peaks.

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