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Abstract #3611

Optimization of redox-state assessment in rat liver using hyperpolarized [1-13C]alanine

Jae Mo Park1,2, Ralph E Hurd3, and Daniel M Spielman2

1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Radiology, Stanford University, Stanford, CA, United States, 3Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States

In this study, we demonstrated the strategies of increasing signal sensitivities of 13C-pyruvate and 13C-lactate generated from an injection of hyperpolarized 13C-alanine by (1) adjusting the alanine dose and (2) co-injecting unlabeled pyruvate. 120-mM alanine produced larger amount of labeled pyruvate and lactate as compared to when 80-mM or 40-mM alanine was injected. The co-injection of 7-mM unlabeled pyruvate showed up to 49% SNR increase in pyruvate and lactate peaks.

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