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Abstract #3620

Defining the optimal post-labeling delay for pCASL using patient specific estimates of blood velocity in the carotid artery

Neville D Gai1 and John A Butman1

1Radiology & Imaging Sciences, NIH Clinical Center, Bethesda, MD, United States

Pseudo-continuous arterial spin labeling (pCASL) with 3D non-segmented acquisition scheme allows assessment of full brain CBF with sufficiently high SNR and resolution in an efficient manner. Post-labeling delay is a critical parameter which needs to be determined preferably on a per subject basis since PLD can change based on the physiological condition of a subject. Multiple post-labeling delay (PLD) pCASL could address this issue. However, multiple PLD pCASL is not feasible for the 3D non-segmented acquisition scheme. In this work, we related the velocity in carotid artery (CA) measured using two schemes to PLD in ten volunteers. A relationship between the CA velocity and optimal PLD was derived which allows for optimal PLD to be determined on the fly for each subject.

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