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Abstract #3622

Improved Calculation of Arterial Blood Equilibrium Magnetization in Arterial Spin Labeling

André Ahlgren1, Ronnie Wirestam1, Freddy Ståhlberg1,2,3, Linda Knutsson1,4, and Esben Thade Petersen5

1Department of Medical Radiation Physics, Lund University, Lund, Sweden, 2Diagnostic Radiology, Lund University, Lund, Sweden, 3Lund University Bioimaging Center, Lund University, Lund, Sweden, 4Department of Radiology (Adjunct), Johns Hopkins School of Medicine, Baltimore, United States, 5Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark

The calibration factor (equilibrium magnetization of arterial blood) in arterial spin labeling is usually calculated by dividing a PD image with a constant brain-blood partition coefficient, $$$\lambda$$$. A more accurate approach would be to divide a map corresponding to the PD of the perfused parenchymal tissue with a $$$\lambda$$$ map (i.e, taking into account different values of $$$\lambda$$$ in different tissue types). In this work, we demonstrate how this can be achieved using partial volume (PV) estimates. In vivo results are demonstrated and compared with the conventional method.

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