The calibration factor (equilibrium magnetization of arterial blood) in arterial spin labeling is usually calculated by dividing a PD image with a constant brain-blood partition coefficient, $$$\lambda$$$. A more accurate approach would be to divide a map corresponding to the PD of the perfused parenchymal tissue with a $$$\lambda$$$ map (i.e, taking into account different values of $$$\lambda$$$ in different tissue types). In this work, we demonstrate how this can be achieved using partial volume (PV) estimates. In vivo results are demonstrated and compared with the conventional method.
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