Abstract #3651

Importance of reference in QSM and a new differential ROI reference method

TaeHyun Hwang¹, JinGu Lee¹, JunYeol Choi¹, SangJoon Kim², GeonHo Jahng³, and Jongho Lee¹

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, ²Department of Radiology, ASAN Medical Center, Korea, Republic of, ³Department of Radiology, Kyung Hee University Hospital at Gangdong, Korea, Republic of

In this study, we developed a computer simulation to demonstrate the importance of reference in QSM. The results show that QSM values are substantially affected by spatial coverage for reconstruction. Only when the data are referenced using a neighboring region, the QSM results provide correct susceptibility values. Additionally, we suggest a new “differential ROI” reference method. This approach reports the susceptibility value as a difference between two (neighboring) ROIs. We demonstrate this new approach for a Parkinson’s disease patient study.

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