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Abstract #3651

Importance of reference in QSM and a new differential ROI reference method

TaeHyun Hwang1, JinGu Lee1, JunYeol Choi1, SangJoon Kim2, GeonHo Jahng3, and Jongho Lee1

1Department of Electrical and Computer Engineering, Seoul National University, Seoul, Korea, Republic of, 2Department of Radiology, ASAN Medical Center, Korea, Republic of, 3Department of Radiology, Kyung Hee University Hospital at Gangdong, Korea, Republic of

In this study, we developed a computer simulation to demonstrate the importance of reference in QSM. The results show that QSM values are substantially affected by spatial coverage for reconstruction. Only when the data are referenced using a neighboring region, the QSM results provide correct susceptibility values. Additionally, we suggest a new “differential ROI” reference method. This approach reports the susceptibility value as a difference between two (neighboring) ROIs. We demonstrate this new approach for a Parkinson’s disease patient study.

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