Abstract #3653

Localization of the implanted brachytherapy titanium seeds in presence of calcification on MR images using Quantitative Susceptibility Mapping (QSM) and 3D K-means clustering

Reyhaneh Nosrati^1,2, Abraam Soliman^3,4, Alexey V. Dimov^5,6, Hirohito Kan⁷, Gerard Morton^8,9, Ana Pejović-Milić¹⁰, and William Song^3,11

¹Medical Physics, Ryerson University, Toronto, ON, Canada, ²Medical Physics, Sunnybrook Health Science Centre, Toronto, ON, Canada, ³Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ⁵Meinig school of Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁶Radiology, Weill Medical College of Cornell University, New York, NY, United States, ⁷Radiology, Nagoya City University Hospital, Nagoya, Japan, ⁸Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁹Radiation oncology, University of Toronto, Toronto, ON, Canada, ¹⁰Physics, Ryerson University, Toronto, ON, Canada, ¹¹Medical Biophysics, University of Toronto, Toronto, ON

Post‐implant dosimetry is an important quality assurance for prostate low‐dose‐rate (LDR) permanent seed brachytherapy. Despite the superior soft tissue contrast in MRI that is required for tumor delineation, there are some unresolved issues with seed depiction on MR images as they appear as signal void. In addition, calcified regions have similar characteristics on MR images making them indiscernible. This work investigates the feasibility of an MR-only workflow based on quantitative susceptibility mapping (QSM) and 3D k-means clustering for post-implant localization of the seeds.

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