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Abstract #3653

Localization of the implanted brachytherapy titanium seeds in presence of calcification on MR images using Quantitative Susceptibility Mapping (QSM) and 3D K-means clustering

Reyhaneh Nosrati1,2, Abraam Soliman3,4, Alexey V. Dimov5,6, Hirohito Kan7, Gerard Morton8,9, Ana Pejović-Milić10, and William Song3,11

1Medical Physics, Ryerson University, Toronto, ON, Canada, 2Medical Physics, Sunnybrook Health Science Centre, Toronto, ON, Canada, 3Medical Physics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, 5Meinig school of Biomedical Engineering, Cornell University, Ithaca, NY, United States, 6Radiology, Weill Medical College of Cornell University, New York, NY, United States, 7Radiology, Nagoya City University Hospital, Nagoya, Japan, 8Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 9Radiation oncology, University of Toronto, Toronto, ON, Canada, 10Physics, Ryerson University, Toronto, ON, Canada, 11Medical Biophysics, University of Toronto, Toronto, ON

Post‐implant dosimetry is an important quality assurance for prostate low‐dose‐rate (LDR) permanent seed brachytherapy. Despite the superior soft tissue contrast in MRI that is required for tumor delineation, there are some unresolved issues with seed depiction on MR images as they appear as signal void. In addition, calcified regions have similar characteristics on MR images making them indiscernible. This work investigates the feasibility of an MR-only workflow based on quantitative susceptibility mapping (QSM) and 3D k-means clustering for post-implant localization of the seeds.

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