Abstract #3662

Changes in brain iron concentration after exposure to high altitude hypoxia by quantitative susceptibility mapping

Lin Chen¹, Congbo Cai², Tianhe Yang³, Jianzhong Lin³, Shuhui Cai¹, Jiaxing Zhang⁴, and Zhong Chen¹

¹Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, ²Department of Communication Engineering, Xiamen University, Xiamen, People's Republic of China, ³Zhongshan Hospital, Xiamen, People's Republic of China, ⁴Department of Physiology and Neurobiology, Xiamen University, Xiamen, People's Republic of China

Environmental factors may influence brain iron concentration. We investigated the changes of magnetic susceptibility and R₂^* values of cerebral regions especially in six deep gray matter nuclei of twenty-nine participants after high altitude exposure for four weeks. The results show that the susceptibility values of gray matter, especially in caudate nucleus, putamen, globus pallidus, substantia nigra, red nucleus, increased significantly. Traditional R₂^* maps verify the results of QSM evaluation except in red nucleus. Therefore, high altitude hypoxia can lead to significant increase of cerebral iron concentration.

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