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Abstract #3662

Changes in brain iron concentration after exposure to high altitude hypoxia by quantitative susceptibility mapping

Lin Chen1, Congbo Cai2, Tianhe Yang3, Jianzhong Lin3, Shuhui Cai1, Jiaxing Zhang4, and Zhong Chen1

1Department of Electronic Science, Xiamen University, Xiamen, People's Republic of China, 2Department of Communication Engineering, Xiamen University, Xiamen, People's Republic of China, 3Zhongshan Hospital, Xiamen, People's Republic of China, 4Department of Physiology and Neurobiology, Xiamen University, Xiamen, People's Republic of China

Environmental factors may influence brain iron concentration. We investigated the changes of magnetic susceptibility and R2* values of cerebral regions especially in six deep gray matter nuclei of twenty-nine participants after high altitude exposure for four weeks. The results show that the susceptibility values of gray matter, especially in caudate nucleus, putamen, globus pallidus, substantia nigra, red nucleus, increased significantly. Traditional R2* maps verify the results of QSM evaluation except in red nucleus. Therefore, high altitude hypoxia can lead to significant increase of cerebral iron concentration.

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