One challenge in Quantitative Susceptibility Mapping (QSM) identified in a recent QSM workshop is zero reference. Cerebrospinal fluid (CSF) with little cellular content has been a popular choice. However, current QSM often shows inhomogeneous CSF, which may be regarded as artifacts caused by surrounding anisotropic white matter fibers in the scalar dipole inversion. We propose a regularization of minimal CSF variation for projecting out CSF inhomogeneity artifacts. Our proposed new QSM incorporates automated segmentation and regularization specific to CSF and outputs susceptibility values with automatic and uniform CSF zero reference. Accordingly, we term this novel QSM method as QSM0
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