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Abstract #3714

SNR Efficiency in Multi-Parameter Mapping (PD, T1 & T2*) at 3T: Comparison of MP2RAGE and VFA-FLASH

Jean-David Jutras1, Keith Wachowicz1,2, Guillaume Gilbert3, and Nicola De Zanche1,2

1Oncology, University of Alberta, Edmonton, AB, Canada, 2Medical Physics, Cross Cancer Institute, Edmonton, AB, Canada, 3MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada

Quantitative parametric mapping is becoming increasingly promising for improving the diagnostic quality and reproducibility of structural brain MR images. The variable flip angle technique with FLASH (VFA-FLASH) is a popular technique for mapping the proton-density, T1 and T2*. Recently, the MP2RAGE pulse sequence was developed to map T1 with robustness to RF inhomogeneity. If a multi-echo (bipolar) MP2RAGE is employed, proton-density and T2* can also be mapped simultaneously. In this study we compare the SNR efficiency and accuracy of VFA-FLASH and MP2RAGE for multi-parameter mapping at 3T. Both methods yield comparable T1-to-noise ratios, but VFA-FLASH is superior for PD and T2* mapping.

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