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Abstract #3716

Whole Body T1 Mapping of Small Animals using Prospective Gating and Variable Flip Angle Imaging

Paul Kinchesh1, Philip D Allen1, John S Beech1, Stuart Gilchrist1, Ana L Gomes1, Veerle Kersemans1, Robert Newman1, Borivoj Vojnovic1, Michael Brady1, Ruth J Muschel1, and Sean C Smart1

1CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom

Prospective gating and automatic reacquisition of data corrupted by respiration motion were implemented in variable flip angle (VFA) and actual flip angle imaging (AFI) scans to enable cardio-respiratory synchronised T1 mapping of the whole mouse. T1 calculation for each mouse took approximately 6 s using a robust and efficient nonlinear least squares process. 16 cardio-respiratory gated VFA scans and a respiration gated AFI scan were acquired in less than 14 minutes. T1 was calculated in the whole mouse with a voxel size of 0.075 mm3 and with a standard deviation less than 6.2% within ROIs from multiple organs.

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