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Abstract #3718

Fast T1 mapping with temperature correction via DWI thermometry, and it application to vitreous oxygen measurement

Shengwen Deng1, Eric Muir2, Wei Zhou3, and Timothy Q. Duong2

1University of Texas Health Science Center at San Antonio, San Antonio, TX, United States, 2University of Texas Health Science Center at San Antonio, 3Radiology, Mayo Clinic

T1 mapping is showing great potential for mapping oxygen in human organs such as eyes and lungs. And yet, accuracy of oxygen using fast T1 imaging methods is of great concern especially in tissue with radical temperature changes. In the current study we improve fast T1 mapping with temperature correction and explore its potential in mapping oxygen in eyes. With combination of inversion-recovery Look-Locker bSSFP and diffusion weighted thermometry, we calibrate the temperature dependence of ADC and T1, and use it to adjust the R1 for measuring partial pressure of oxygen(pO2). Fast T1 mapping could be a reliable way to pO2 that well agrees with invasive oxygen-sensitive optic fibers.

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