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Abstract #3721

Quantitative 3D T1 mapping technique in rat brain using VFA-FLASH at 9.4T

Hedok Lee1, Simon Sanggaard2, Kristian Mortensen2, Palle Koch2, Maiken Nedergaard2,3, and Helene Benveniste1

1Anesthesiology, Yale University, New Haven, CT, United States, 2Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark, 3Neurosurgery, University of Rochester, NY, United States

3D whole brain T1 mapping technique at 9.4T is studied because of a lack of methodological consideration in spite of its utility in pre-clinical paramagnetic and manganese contrast enhanced imaging studies. We report a simple and accurate 3D T1 mapping technique using variable flip angles spoiled gradient echo sequence with B1+ correction. Accuracy of the technique was validated using phantoms and a population averaged 3D rat T1 map was constructed.

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