Abstract #3721

Quantitative 3D T1 mapping technique in rat brain using VFA-FLASH at 9.4T

Hedok Lee¹, Simon Sanggaard², Kristian Mortensen², Palle Koch², Maiken Nedergaard^2,3, and Helene Benveniste¹

¹Anesthesiology, Yale University, New Haven, CT, United States, ²Center for Basic and Translational Neuroscience, University of Copenhagen, Copenhagen, Denmark, ³Neurosurgery, University of Rochester, NY, United States

3D whole brain T1 mapping technique at 9.4T is studied because of a lack of methodological consideration in spite of its utility in pre-clinical paramagnetic and manganese contrast enhanced imaging studies. We report a simple and accurate 3D T1 mapping technique using variable flip angles spoiled gradient echo sequence with B1+ correction. Accuracy of the technique was validated using phantoms and a population averaged 3D rat T1 map was constructed.

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