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Abstract #3724

Assessing the Accuracy of T2 and B1+ Maps Estimated from Multi-echo Spin Echo MRI Sequences Using Extended Phase Graph Signal Predictions

Nuno Saraiva Santos1,2, Rui Pedro A G Teixeira3, Joseph V Hajnal3, and Rita G Nunes1,2,3

1Institute for Systems and Robotics / Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal, 2Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisbon, Portugal, 3Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

Interpretation of T2-weighted images still remains highly reliant on subjective clinical evaluation. Quantitative mapping using the gold standard approach (single spin-echo), although appealing, remains unfeasible in clinical practice. Multi-SE sequences have emerged as viable solutions allowing much shorter scan times at the expense of signal contamination by indirect echoes. A method based on the MR Fingerprinting concept has recently been proposed, estimating T2 and B1+ maps from pre-computed Echo Modulation Curves. This study evaluated the performance of this method performing Monte Carlo simulations followed by an in vivo acquisition. The method provided accurate T2 maps, despite highly biased B1+ estimates.

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