Abstract #3745

3D-CEST Imaging of a Mouse Model of Polycystic Kidney Disease

Shanrong Zhang¹, Matanel Yheskel², Vishal Patel², Masaya Takahashi¹, and A. Dean Sherry¹

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Department of Internal Medicine and Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, United States

The objective is to develop a new 3D-CEST imaging method (3-dimensional chemical exchange saturation transfer) to investigate a mouse model of polycystic kidney disease (PKD). It is based on 3D magnetization prepared rapid acquisition gradient echo sequence (3D MPRAGE) by applying a pre-saturation pulse consisting of three continuous Gauss shaped pulses.

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