The origin of the Nuclear Overhauser Enhancement (NOE) signal observed in the CEST spectrum of the brain is still under debate. The effect is detected upfield from water, in the frequency range of non-exchangeable aliphatic/olefinic protons, indicating that the transfer of magnetization is not occurring via proton or chemical exchange; furthermore the lineshape is relatively narrow, suggesting the signal is coming from mobile protons with T2 of the order of 300μs. This study investigates the correlation between NOE and MT in the human brain at 7T, and shows the two effects are strongly coupled, across a wide age range.
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