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Abstract #3782

CEST and NOE signals in ischemic stroke at 9.4T evaluated using a Lorentzian multi-pool analysis: a drop, an increase or no change?

Yee Kai Tee1, Badrul Abidin1, Alexandr Khrapitchev2, Brad A Sutherland3,4, James Larkin2, Kevin Ray2, George Harston4, Alastair M Buchan4, James Kennedy4, Nicola R Sibson2, and Michael A Chappell5

1Department of Mechatronics and Biomedical Engineering, Universiti Tunku Abdul Rahman, Kajang, Malaysia, 2Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, United Kingdom, 3School of Medicine, Faculty of Health, University of Tasmania, Australia, 4Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, United Kingdom, 5Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, United Kingdom

CEST and NOE effects in ischemic stroke at 9.4T were studied using a Lorentzian multi-pool approach. It was found that both the CEST and NOE signals had significant changes in region of acute ADC reduction when compared with contralateral tissue. The contrast or relative values to the contralateral tissues of MTRasym(3.5 ppm) was found to correlate moderately strongly with the relative amide signal at 3.5 ppm but not the relative reference signal at –3.5 ppm, suggesting that it is should be used in the group analysis in a population-wide basis to assess the change of APT in the ischemic stroke.

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