Abstract #3782

CEST and NOE signals in ischemic stroke at 9.4T evaluated using a Lorentzian multi-pool analysis: a drop, an increase or no change?

Yee Kai Tee¹, Badrul Abidin¹, Alexandr Khrapitchev², Brad A Sutherland^3,4, James Larkin², Kevin Ray², George Harston⁴, Alastair M Buchan⁴, James Kennedy⁴, Nicola R Sibson², and Michael A Chappell⁵

¹Department of Mechatronics and Biomedical Engineering, Universiti Tunku Abdul Rahman, Kajang, Malaysia, ²Cancer Research UK & Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, United Kingdom, ³School of Medicine, Faculty of Health, University of Tasmania, Australia, ⁴Acute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, United Kingdom, ⁵Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, United Kingdom

CEST and NOE effects in ischemic stroke at 9.4T were studied using a Lorentzian multi-pool approach. It was found that both the CEST and NOE signals had significant changes in region of acute ADC reduction when compared with contralateral tissue. The contrast or relative values to the contralateral tissues of MTRasym(3.5 ppm) was found to correlate moderately strongly with the relative amide signal at 3.5 ppm but not the relative reference signal at –3.5 ppm, suggesting that it is should be used in the group analysis in a population-wide basis to assess the change of APT in the ischemic stroke.

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