(ISMRM 2017) Longitudinal in vivo 19F MR imaging by ZTE of 19F labeled calcium phosphate cement implanted in bone defects in the rat
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Abstract #3784

Longitudinal in vivo 19F MR imaging by ZTE of 19F labeled calcium phosphate cement implanted in bone defects in the rat

Weiqiang Dou1, Simone Mastrogiacomo2, Olga Koshkina3, Andor Veltien1, Mangala Srinivas3, X. Frank Walboomers2, and Arend Heerschap1

1Radiology, Radboud University Medical Centre, Nijmegen, Netherlands, 2Biomaterials, Radboud University Medical Centre, Nijmegen, Netherlands, 3Tumor Immunology, Radboud University Medical Centre, Nijmegen, Netherlands

To enhance MR image contrast of calcium phosphate cement (CPC) to bone, CPC was tagged with 19F loaded nanoparticles. This 19F labeled CPC material, after implantation into bone defects in rat legs, was monitored in vivo at 11.7T by longitudinal 19F zero echo time (ZTE) MR imaging. We demonstrate that the overlay of 19F ZTE images on 1H images allows for an excellent qualitative view of CPC with no background. By a quantitative evaluation of the 19F signal the in vivo degradation of CPC over weeks can be followed by MRI.

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Keywords

in vivo