Abstract #3784

Longitudinal in vivo 19F MR imaging by ZTE of 19F labeled calcium phosphate cement implanted in bone defects in the rat

Weiqiang Dou¹, Simone Mastrogiacomo², Olga Koshkina³, Andor Veltien¹, Mangala Srinivas³, X. Frank Walboomers², and Arend Heerschap¹

¹Radiology, Radboud University Medical Centre, Nijmegen, Netherlands, ²Biomaterials, Radboud University Medical Centre, Nijmegen, Netherlands, ³Tumor Immunology, Radboud University Medical Centre, Nijmegen, Netherlands

To enhance MR image contrast of calcium phosphate cement (CPC) to bone, CPC was tagged with ¹⁹F loaded nanoparticles. This ¹⁹F labeled CPC material, after implantation into bone defects in rat legs, was monitored in vivo at 11.7T by longitudinal ¹⁹F zero echo time (ZTE) MR imaging. We demonstrate that the overlay of ¹⁹F ZTE images on ¹H images allows for an excellent qualitative view of CPC with no background. By a quantitative evaluation of the ¹⁹F signal the in vivo degradation of CPC over weeks can be followed by MRI.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.