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Abstract #3794

Diffusion effects on NMR transverse relaxation around randomly distributed capillaries

Lukas Reinhold Buschle1,2, Christian H Ziener1, Martin R├╝ckl3, Ke Zhang1,2, Volker J Sturm1,2, Gergely M Solecki4, Frank Winkler4, Martin Bendszus2, Sabine Heiland2, Heinz-Peter Schlemmer1, and Felix T Kurz1,2

1E010 Radiology, German Cancer Research Center, Heidelberg, Germany, 2Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, 3Department of Physics, Humboldt University Berlin, Berlin, Germany, 4Neurooncology, German Cancer Research Center, Heidelberg, Germany

The gradient echo and spin echo signal in brain tissue depend both on diffusion and susceptibility effects around and from capillaries, i.e. on structural and functional information that arise from the microvascular networks. In this work, the dependence of the relaxation rates R2 and R2* on capillary radius are considered for a random arrangement of capillaries in the strong collision approximation, and a closed-form solution is derived. Radius maps are then constructed for glioblastoma mice (N=8) to reveal an increased vessel radius in tumorous tissue as compared to non-affected brain tissue.

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