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Abstract #3796

Dynamic Blood Volume Assessment in Extracranial Tissues using Gadofosveset

Tameshwar Ganesh1,2, Marvin Estrada3, James Duffin4, and Hai-Ling Margaret Cheng1,2,5,6

1Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 2Ted Rogers Centre for Heart Research, Translational Biology & Engineering Program, Toronto, ON, Canada, 3Lab Animal Services, Hospital for Sick Children, 4Anesthesia, University of Toronto, Canada, 5The Edward S. Rogers Sr. Department of Electrical & Computer Engineering, University of Toronto, Toronto, ON, Canada, 6Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, ON, Canada

The ability of blood vessels to modulate vascular tone (i.e. blood volume) is an important normal physiological function, which is compromised in multiple diseases, including diabetes and heart diseases. To date, there is no non-invasive imaging technique to assess dynamic microvascular blood volume response. Herein we present a novel MRI technique to assess vasoactive response in “near” real-time in extra-cranial tissues. We employ a blood-pool agent Gadofosveset (Vasovist) together with a variety of vasoactive gas stimuli. In-vivo results in kidney and liver demonstrate we can visualize dynamic changes in gas-induced blood volume changes, as confirmed on laser Doppler perfusion.

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