Abstract #3804

Tagging distance dependent Z-spectrum (TADDZ) for ASL MRI free from B0-inhomogeneity induced errors

Frederick C. Damen^1,2, Rong-Wen Tain^1,2, Weigo Li³, Xiaohong Joe Zhou^1,2, Leon Tai⁴, and Kejia Cai^1,2

¹Radiology, University of Illinois at Chicago, Chicago, IL, United States, ²Center for Magnetic Resonance Research 3T Program, University of Illinois at Chicago, Chicago, IL, United States, ³Research Resources Center, University of Illinois at Chicago, Chicago, IL, United States, ⁴Anatomy and Cell Biology, Chicago, IL, United States

Arterial spin labeling (ASL) MRI, based on endogenous contrast from blood water, is used for research and diagnosis of cerebral vascular conditions. However, artifacts due to imperfect imaging conditions such as B₀ inhomogeneity could lead to variations in the quantification of cerebral blood flow (CBF). In this study, we investigated the CBF variation artifacts due to B₀‑inhomogeneity using Signal Targeting with Alternating Radio frequency (STAR) based ASL. We developed a novel technique, TADDZ, similarly to the corrections for chemical exchange saturation transfer (CEST) experiments, to remove the B₀ inhomogeneity induced CBF artifacts.

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