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Abstract #3804

Tagging distance dependent Z-spectrum (TADDZ) for ASL MRI free from B0-inhomogeneity induced errors

Frederick C. Damen1,2, Rong-Wen Tain1,2, Weigo Li3, Xiaohong Joe Zhou1,2, Leon Tai4, and Kejia Cai1,2

1Radiology, University of Illinois at Chicago, Chicago, IL, United States, 2Center for Magnetic Resonance Research 3T Program, University of Illinois at Chicago, Chicago, IL, United States, 3Research Resources Center, University of Illinois at Chicago, Chicago, IL, United States, 4Anatomy and Cell Biology, Chicago, IL, United States

Arterial spin labeling (ASL) MRI, based on endogenous contrast from blood water, is used for research and diagnosis of cerebral vascular conditions. However, artifacts due to imperfect imaging conditions such as B0 inhomogeneity could lead to variations in the quantification of cerebral blood flow (CBF). In this study, we investigated the CBF variation artifacts due to B0‑inhomogeneity using Signal Targeting with Alternating Radio frequency (STAR) based ASL. We developed a novel technique, TADDZ, similarly to the corrections for chemical exchange saturation transfer (CEST) experiments, to remove the B0 inhomogeneity induced CBF artifacts.

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