Abstract #3835

Quantitative Susceptibility Mapping Using 2D Simultaneous Multi-slice Gradient-echo Imaging at 7T

Wei Bian¹, Adam Bruce Kerr², Kongrong Zhu², Paymon Rezaii¹, Maged Goubran¹, Christopher Lock³, May Han³, Yi Wang⁴, Zhe Liu⁴, Sherveen Parivash¹, Brian Rutt¹, and Michael Zeineh¹

¹Department of Radiology, Stanford University, Stanford, CA, United States, ²Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ³Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, United States, ⁴Department of Radiology, Weill Cornell Medical College, New York, NY

A 2D multi-echo simultaneous multi-slice (SMS) gradient-echo imaging sequence was implemented for simultaneous anatomical imaging, R2* mapping and quantitative susceptibility mapping (QSM). Imaging acceleration in the slice direction speeds up the sequence to clinical scan times while using a longer TR and larger flip angle compared to 3D imaging. Evaluation from both healthy and multiple sclerosis subjects showed that, using the same acquisition time and imaging resolution as a 3D sequence, the proposed sequence improved tissue susceptibility contrast, suggesting 2D SMS GRE imaging may be a viable alternative for clinical applications of susceptibility-based imaging.

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