Abstract #3879

Correlating ZTE MRI signal to bone density to derive a patient-specific attenuation correction map in brain PET/MR

Maya Khalifé¹, Brice Fernandez², Olivier Jaubert¹, Michael Soussan³, Irène Buvat³, Vincent Brulon³, and Claude Comtat³

¹Brain and Spine Institute (ICM), Hôpital de la Pitié-Salpêtrière, Paris, France, ²Applications and Workflow, GE Healthcare, Orsay, France, ³Laboratoire d’Imagerie Moléculaire In Vivo (IMIV), Commissarriat à l'Energie Atomique et aux Energie Alternatives (CEA), Orsay, France

Attenuation correction (AC) is needed for an accurate PET image quantification in brain PET/MR. Regular MRI cannot distinguish between different tissue types based on electron density, thus, Zero Echo Time (ZTE) has been used to segment bone, air and soft tissue. Furthermore, a correlation has been established between histogram normalized ZTE intensity and measured CT density in Hounsfield Unit (HU) in bone on a CT-MR database of 16 patients. The patient-specific AC map generated by combining ZTE-based segmentation and linear scaling of normalized ZTE signal into HU showed to be a good substitute of the measured CT-AC map in brain PET/MR.

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