Meeting Banner
Abstract #3890

PET-MRI in hepatocellular carcinoma: Correlation of DCE-MRI perfusion quantification using shutter-speed model with FDG uptake

Stefanie Hectors1, Mathilde Wagner1, Cecilia Besa1, Wei Huang2, and Bachir Taouli1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR, United States

Shutter-speed modeling (SSM) of DCE-MRI data allows for estimation of the mean intracellular water molecular lifetime (τi), which has been suggested to be associated with tissue metabolic activity. In this study, we assessed the correlation between SSM DCE-MRI parameters and FDG-PET uptake in hepatocellular carcinoma (HCC) lesions. While Ktrans did show a significant negative correlation with the standardized uptake value (SUV) in the HCC lesions, τi was not significantly associated with FDG uptake. Our preliminary findings suggest that τi may not be associated with the up-stream tumor glucose metabolism as measured by FDG-PET.

This abstract and the presentation materials are available to members only; a login is required.

Join Here