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Abstract #3929

PET motion correction by co-registering multiple MR contrasts in simultaneous brain MR-PET

Francesco Sforazzini1, Richard McIntyre1,2, Nicholas Ferris1, Nadim Jon Shah1,3,4, Gary Egan1,5,6, and Zhaolin Chen1,4

1Monash Biomedical Imaging, Monash University, Melbourne, Australia, 2Monash Medical Centre, Clayton, Australia, 3Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, Jülich, Germany, 4Department of Electrical and Computer Systems Engineering, Monash University, Monash University, Melbourne, Australia, 5Australian Research Council Centre of Excellence for Integrative Brain Function, Monash University, Melbourne, Australia, 6Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Melbourne, Australia

Head movement is a major issue in dynamic brain PET imaging. The introduction of a simultaneous MR-PET scanner enabled new opportunities to use MR information for PET motion correction. Here we present a novel method based on routinely acquired MRI sequences. Multi-contrast MR images are co-registered to extract motion parameters. These motion parameters are then used to guide PET image reconstruction. Results on both phantom and human data provide evidences that this method can significantly enhance image contrast and reduce motion artefact in brain PET images, without affecting MR protocol.

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